advanced solid tumors — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3124	Carbendazim	Bavistin,Carbendazole,Mercarzole	Antifungal
	Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspec...		Antifungal
T26978	CEP-40125	RXDX-107	DNA Alkylation
	CEP-40125 (RXDX-107) is a DNA alkylating agent for the study of advanced solid tumors.		DNA Alkylation
T79157	Pimicotinib	ABSK021,ABSK-021	c-Fms , Others
	Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.		c-Fms , Others
T36395	Trotabresib	CC-90010	Epigenetic Reader Domain
	Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.		Epigenetic Reader Domain
T2113	PHA-793887	PHA 793887,PHA793887	Apoptosis , CDK
	PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.		Apoptosis , CDK
T76706	Varlilumab	CDX-1127	TNF
	Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.		TNF
T40199	Tulmimetostat	CPI-0209	Histone Methyltransferase
	Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced solid tumors.		Histone Methyltransferase
T77750	Rosmantuzumab	OMP-131R10	Others
	Rosmantuzumab (OMP-131R10) is a humanized monoclonal antibody against R-spondin 3 (RSPO3). Rosmantuzumab has potential antitumor activity and can be used to study advanced relapsed refractory solid tumors.		Others
T77138	Ragifilimab	INCAGN-01876,INCAGN-1876,CM-701	TNF
	Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting glucocorticoid-induced TNFR-associated protein (GITR). Ragifilimab can be used in the study of advanced or metastatic solid tumors.		TNF
T83970	IMMH 010 maleate	YPD-30 maleate	PD-1/PD-L1
	IMMH 010 maleate (YPD-30 maleate) is an orally available programmed cell death ligand 1 inhibitor with potential antitumor activity for the study of neurological disorders and advanced malignant solid tumors.		PD-1/PD-L1
T2709	TAK-901	TAK901	JAK , CDK , Src , Aurora Kinase
	TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others.		JAK , CDK , Src , Aurora Kinase
T6084	Rabusertib	LY2603618,IC-83	Chk , PDK , Autophagy
	Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cance...		Chk , PDK , Autophagy
T6157	Devimistat	CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid	Apoptosis , Dehydrogenase , Mitochondrial Metabolism
	Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent...		Apoptosis , Dehydrogenase , Mitochondrial Metabolism
T0078L	Lapatinib ditosylate monohydrate	Lapatinib ditosylate monohydrate,Lapatinib ditoluenesulfonate monohydrate,Lapatinib tosilate hydrate,Lapatinib tosilate,Tykerb,Tyverb	EGFR , Ferroptosis , Autophagy
	Lapatinib ditosylate (Lapatinib tosilate) monohydrate is a tyrosine kinase receptor inhibitor used in the therapy of advanced breast cancer and other solid tumors. Lapatinib ditosylate monohydrate therapy is associated w...		EGFR , Ferroptosis , Autophagy
T11500L	GSK3368715 dihydrochloride	EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl	Histone Methyltransferase
	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs) with anticancer and antitumor activity, inhibiting PRMT1, PRMT3, PRMT4...		Histone Methyltransferase
T76787	Conatumumab	TRAIL-R2 mAb,AMG 655	TNF
	Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 (DR5, TRAILR2) at Kd 1 nM for long DR5 and Kd 0.8 nM for short DR5. Conatumumab induces apoptosis in a variety of tumor types throug...		TNF
T24176	(-)-Irofulven	MGI-114,NSC-683863,MGI 114,HMAF,MGI114,Irofulven
	Irofulven is an agent of DNA-damaging and antitumor. It is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.
T77120	Opucolimab
	Opucolimab, an anti-PD-L1 recombinant human monoclonal antibody, has applications in synthesizing antibody-agent conjugates and is utilized in research targeting advanced solid tumors [1].
T69759	IACS-9439		c-Fms
	IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM. It is applicable in the research of advanced solid tumors [1].		c-Fms
T76929	Betifisolimab
	Betifisolimab (MSB-2311), a humanized monoclonal antibody targeting the immunosuppressive ligand PD-L1, shows promise for research in advanced solid tumors and hematological malignancies [1].